Despite the strong suspicion between genetics and asthma, genetic mutations account for only a fraction of the risk of disease development, a new study suggests. Rarely low-frequency genetic mutations are thought to explain this missing genetic, but they cannot play an important role. There are more than 11,000 people in the coding region for the analysis of the genome. Scientists have found that mutations in only three genes are associated with the risk of asthma. These three genes include GRASP, GSDMB and MTHFR. Studies have shown that the gap is in the genetic understanding of asthma. "Previous studies may have overestimated the heritability of asthma, probably because these estimates are based on family members sharing the environment and the correlation between genes, which may exaggerate heritability," said Carole Ober, Department of Human Genetics, University of Chicago. Say.
Previous studies did not consider the interaction between genes and the environment. These risks of establishing individual asthma are particularly important. Catherine Igartua of the University of Chicago evaluated nearly 33,000 rare or low frequency mutations in more than 11,000 people of different races. She uses a technique that allows her to study a common mutation in a nation, but it is rare. These genes, involved in apoptosis-regulating protein scaffolds, and vitamin B9 metabolism, are unknown roles in asthma, so far. Although rare mutations may not contribute much to the risk of asthma in the population, these genes still serve as potential therapeutic targets for development. "We think that there will be greater impact than we have been studying rare mutations in common variants," Ober said.
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